COVID?19 and SARS?CoV?2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease

Severe acute respiratory syndrome (SARS) coronavirus?2 (SARS?CoV?2), the causative viral agent for ongoing COVID?19 pandemic, enters its host cells primarily via binding of SARS?CoV?2 spike (S) proteins to angiotensin?converting enzyme 2 (ACE2). A number other cell entry mediators have also been identified, including neuropilin?1 (NRP1) and transmembrane protease serine (TMPRSS2). More recently, it has demonstrated that 4 (TMPRSS4) along with TMPRSS2 activate S proteins, enhance infection human small intestinal enterocytes. To date, a systematic analysis TMPRSS4 in health disease is lacking. In present study, using in silico tools, gene expression genetic alteration were analysed across numerous tumours compared controls. The observations expanded level central nervous system (CNS). findings revealed was overexpressed 11 types cancer, lung adenocarcinoma, squamous carcinoma, cervical thyroid ovarian cancer rectum, pancreatic colon stomach uterine carcinosarcoma corpus endometrial whilst significantly downregulated kidney carcinomas, myeloid leukaemia, skin cutaneous melanoma testicular germ tumours. Finally, high documented olfactory tubercle, paraolfactory gyrus frontal operculum, all brain regions which are associated sense smell taste. Collectively, these data suggest may play role symptomatology as another mediator responsible tropism this coronavirus both periphery CNS.